Step 3 · Mix · Homogenize · Mill
FagronLab™ EMP PRO
High-volume planetary mixer with melting and deaeration
The FagronLab™ PM300 PRO is an all-in-one planetary device that integrates mixing, melting and deaeration for pharmacies preparing formulations above 100 mL. With a production capability of 215 mL inside a 310 mL nominal volume, and user-defined time (up to 30 minutes) and speed (up to 2200 rpm), it standardizes high-volume compounding preparation while safeguarding formulation safety, quality and effectiveness.
How it is used
- Creams, gels and ointments with soluble, liquid or insoluble APIs.
- Gelatin bases, gums, mucosal and oral films.
- Suppositories and vaginal inserts, including the melting step.
- Deaeration of preparations above 125 mL prepared in other devices.
- Hazardous drug compounding in a fully closed jar.
Advantages
- Single-step process
- Dosage accuracy
- Compounding substances of varying densities
- Thermal regulation
- Convenient elevation in production volume
- Standardization through parameter storage
- Timesaving
- Compounding hazardous drugs
- Conservation of resources
- Material-loss prevention
Operating parameters
Source: FagronLab™ Formulation Guide. Always follow the parameters for your jar size and API concentration.
Operating modes
Revolution speed is selected by the pharmacist; rotation quantity changes with the selected mode and revolution speed, standardizing the process across batches.
| Mode | Function |
|---|---|
| Mixing | Homogenization of substances with similar and varying densities. |
| Medium | Sustains temperature and prevents air entrapment during mixing. |
| Deaeration (degas) | Compounding deaeration and maintenance of a consistent temperature. |
| Waving | Homogeneous mixing at controlled temperature regardless of viscosity differences. Not suggested for deaeration. |
PM300 PRO functions and use in a workflow
| Dosage form | Role of the PM300 PRO | Suggested combination |
|---|---|---|
| Cream / Gel / Ointment (soluble or liquid APIs) | Mixing, deaeration | — |
| Cream / Gel / Ointment (insoluble APIs) | Mixing, deaeration | FagronLab™ ION-e (electrostatic-free powder handling); FagronLab™ EMP (suspended APIs) |
| Cream / Gel / Ointment (uneven particle size, pre-grinding) | Mixing, deaeration | FagronLab™ ION-e; FagronLab™ InvoMatic (grinding) |
| Gel / gum formation (gelatine) | Mixing, melting, deaeration | — |
| Suppository / vaginal insert | Mixing, melting, deaeration | FagronLab™ ION-e; FagronLab™ suppository molds and accessories |
| Oral film | Mixing, melting, deaeration | FagronLab™ ION-e |
| Preparations above 125 mL | Deaeration | FagronLab™ ION-e; FagronLab™ EMP (incorporation) |
Accessories
The accessory range keeps growing — grinding spheres, metal jar compatibility and new adapters are in the pipeline.
| Accessory | Description |
|---|---|
| PM jar 215 mL | Reusable standard mixing jar with a fully closed structure for mixing, melting and deaeration of low- and high-viscosity semisolid preparations. |
| PM-Jar 100 mL HV | Sterile, disposable jar for deaeration and mixing of gels, creams and ointments. The bottom pushes upward to dispense the remaining volume and reduce air contact. Also compatible with FagronLab™ EMP devices. |
| PM-Jar 125 mL HV+LV | Sterile, disposable fixed-bottom jar for more fluid formulas, also suitable for creams, ointments, gels and mucosal films. Heat resistant to 80 °C and reaches 40 °C; apply external heating (e.g. hot water bath) above 40 °C. |
| PM jar holder | Securely holds the 100 mL HV and 125 mL HV+LV jars during high-speed operation. |
| PM300 PRO spacer | Bridges the capacity difference between devices so every PM jar designed for the PM140 can be used in the PM300 PRO. |
What it delivers
Air entrapment eliminated
Dedicated deaeration removes the unknown, uneven air that compromises homogeneity, dosage accuracy and stability.
Uniform mixing
Standardized speed and applied force make the quality of each compounded preparation reproducible.
Controlled melting
In-device thermal regulation avoids the temperature fluctuation and water-vapor contamination risk of a water bath.
Higher volumes without extra steps
215 mL per batch in a single mixing, melting and deaeration cycle for preparations above 100 mL.
Mechanism of action
The PM300 PRO works through planetary motion — the simultaneous revolution and rotation of the PM jar in opposite directions. The pharmacist selects the revolution speed according to the compounding requirement, while the quantity of rotation changes with the selected mode and revolution speed.
Four distinct modes standardize those changes so preparation stays reproducible: Mixing, Medium, Deaeration (degas) and Wave.
The compounding challenges it solves
Air entrapment: entrapped air is difficult to eliminate and causes dosage inaccuracy, instability from contact between emulsion droplets and air, and microbial proliferation.
Uniformity in mixing: speed and applied force must be standardized to reproduce the quality of compounded preparations batch after batch.
Uniformity in melting bases: conventional methods fluctuate in average temperature and carry a high contamination risk, such as water vapor from a water bath.
Why parameters matter
Mixing speed, time and applied heating must be tailored to each formulation to achieve effective and consistent results.
Interaction between oxidative molecules in the air and formulation components can trigger chemical instabilities, including alterations in texture and pH — so a mixer with deaeration capability is significant for advanced compounding quality.
Specifications
- Production capacity
- 215 mL
- Nominal jar volume
- 310 mL
- Speed
- Up to 2200 rpm
- Timer
- Up to 30 minutes
- Modes
- Mixing, Medium, Deaeration (degas), Wave
- Functions
- Mixing, melting and deaeration in a single step
- Motion
- Planetary — simultaneous revolution and rotation of the PM jar in opposite directions
- Standardization
- Parameter storage for reproducible cycles
- Jar compatibility
- PM jar 215 mL; all PM140 jars via the PM300 PRO spacer
Questions about equipment?
Contact your Fagron Equipment Representative, Nicholas Fournarakis
Nicholas can help with pricing, demos, installation, training and service for any FagronLab™ instrument or workflow.
Nicholas.Fournarakis@fagron.usContact Fagron
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