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18 KG Item No. 697376 | 4.5 KG Item No. 697321 | 500 G Item No. 697322
HRT Heavy™
Hormone therapy cream
HRT Heavy™ is a hormone therapy topical cream base — an excipient made from inactive ingredients for further processing. Its rich, occlusive body carries high hormone loads while remaining elegant on application, making it a dependable vehicle for bio-identical hormone replacement compounding.
- Hormone therapy topical cream base
- Excipient made from inactive ingredients for further processing
- Supports high API loading with a smooth, non-greasy finish
- Available in 500 gram jars
Peer-reviewed studies
- Compatibility of various hormones in Phytobase and HRT Heavy cream basesInternational Journal of Pharmaceutical Compounding (Jan–Feb) · 2024 — Peer-reviewed compatibility assessment of estradiol, estriol, progesterone and testosterone compounded in Phytobase and HRT Heavy cream bases.
- Extended chemical and microbial stability of various hormones in Phytobase and HRT Heavy cream basesInternational Journal of Pharmaceutical Compounding (Jul–Aug) · 2024 — Extended beyond-use-date data covering chemical assay and microbial stability of hormone preparations in Phytobase and HRT Heavy.
- Dermal irritability, sensitization and phototoxicity evaluation of HRT HeavyKosmoscience — dermatologist-supervised clinical report · 2018 — Clinical safety testing of HRT Heavy for primary and accumulated dermal irritation, sensitization, photosensitivity and phototoxicity.
- Percutaneous absorption of progesterone in vitro using the EpiDerm skin modelIn vitro transdermal study — Franz diffusion cells · 2019 — Comparative percutaneous absorption of progesterone from HRT Botanical, HRT Heavy Anhydrous Base and PENCream over a 12-hour dose period.
- HRT Heavy transdermal studies — 5% progesteroneHumco white paper · 2019 — White paper summarizing percutaneous absorption pharmacokinetics of 5% progesterone compounded in HRT Heavy, measured by HPLC in human epidermal cultures.
BUD studies with HRT Heavy™
Estradiol 0.1% in HRT Heavy
Room temperature, LDPE jar
180 days
Progesterone 10% in HRT Heavy
Room temperature, LDPE jar
180 days
Testosterone 2% in HRT Heavy
Room temperature, topi-click dispenser
180 days
Formulas using HRT Heavy™
Testosterone 2 mg/g (0.2%) Cream (HRT Heavy) (BUD Study)
FA-24545
Testosterone 15 mg/g Cream (HRT Heavy) (BUD Study)
FA-24532
Estradiol 1 mg - Progesterone 150 mg - Testosterone 2 mg/g Cream (HRT Heavy) (BUD Study)
FA-24496
Estriol 0.834 mg - Estradiol 0.834 mg/g (Biest 1.6675 mg/g 50:50) Cream (HRT Heavy) (BUD Study)
FA-24494
Fagron Base Comparison Chart
Compare every base side by side — creams and ointments, transdermal creams, and gels.